Picria fel-terrae extract has been investigated for its hepatoprotective activity. This current\nstudy was conducted to evaluate the subchronic toxic effect of Picria fel-terrae Lour. leaf extract.\nThe subchronic toxicity of ethanol extract of P. fel-terrae leaf was evaluated by OECD (Organization\nfor Economic Cooperation and Development) guidelines. The extract at doses of 125, 250, 500,\n1000 mg/kg body weight (BW) were orally administered to the test animals for 90 days. Signs of\ntoxicity and mortality were observed for 90 days and 118 days. The biochemistry, hematology,\nmacropathology, relative organ weight and histopathology examination was also performed.\nThe macroscopic and microscopic examinations of liver, lung, kidney, spleen and heart displayed\nnormal color and texture after treatment, with ethanol extract P. fel-terrae leaf at doses of 125 and\n250 mg/kg BW. The signs of toxicity, mortality, macroscopic and microscopic changes, as well as\nincreasing biochemistry parameters were observed after treatment, with extract at the dose of 500 and\n1000 mg/kg BW. However, the abnormal value of biochemistry parameters was returned to normal\nwhen the treatment was stopped. There was no effect on hematological parameters at all doses of\nextract. The ethanol extract P. fel-terrae leaf is untoxic for long-term use at dose 125 and 250 mg/kg\nBW. The toxic effect of P. fel-terrae at 500 and 1000 mg/kg BW was reversible.
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